Monday, June 06, 2011

iVF program starts - all the scanning tests ,injections

Thursday, May 19, 2011

IVF - 2 week waiting

6 June 2011:

1 Embryo transfer in at 2pm.
Before the transfer could begin I was briefed by the embryologist that only 1 embryo fertilized successfully. The embryo grew to 4 cells on 2 days culture. A photo snapshot on the 4 cells embryo was taken .
Doctor show the procedure on the ultrasound monitor screen. it was a very quick procedure that only took less than 5mins.
My bladder was So full i couldn't bare laying on the bed for more 15mins, it's very uncomfortable laying down in a cold room .

Instructed by the nurse I would need to return on the 10 June 2011 , morning to do a blood test check on my progesterone level
And the final check on the pregnancy test was to conduct on the 20 June 2011 morning.

I thoughts was pretty negative as the day began with a cold raining day, a bad sign for starting.
My body felt cold on the afternoon. There seems no warm sunlight to warm me up.

On the way back home , I had a tea break of a Milo drink n a cold cheese hams. That caused me to have a upset stomach , I had a mild diarreo . Another bad sign for today. I Took quite a lot of warm water to warm me back.

My daring hubby cooked fried rice for me for dinner that immediately warms me up for the coldness.

13 days left . I wonder tomorrow will be a better day for me.

Monday, March 14, 2011

Tablet release in 2011 - Motorola Xoom

Shipping to Singapore by sgbest.com , Order here

Motorola XOOM Android Tablet US$799 , US$599 wifi only

Product Features

  • Next-generation tablet with 10.1-inch display, Android 3.0 platform, and Verizon Wireless mobile broadband connectivity
  • Powered by NVIDIA Tegra 2 dual-core mobile processor; support for Adobe Flash for viewing web sites, movies, games, and more
  • Front-facing 2-megapixel camera and microphone for video chats; rear 5-megapixel camera for high-res stills and HD 720p video
  • 32 GB internal memory; Wireless-N Wi-Fi with Mobile Hotspot capabilities; HDMI output; microSD expansion (with software upgrade)
  • Up to 10 hours of video playback/Wi-Fi web browsing and up to 336 hours (14 days) of standby time; released in 25 February, 2011

Dimensions

  • Size (LWH): 7.48 inches, 4.74 inches, 0.47 inches
  • Weight: 13.6 ounces

Product Features

  • Network Compatibility: CDMA
Cons:

1. There is no comfortable way to hold the Xoom while using it for more than a couple of minutes.
2. It feels very heavy when holding it with one hand for more than a couple of minutes.
3. Many of the apps in the market place crash.
4. Many of the apps in the market place are designed for a small smartphone screen and only fill a small portion of the screen.
5.No micro-usb charging. Motorola makes you drag around a clunky old one-of-a-kind A/C adapter to charge the Xoom
6. The volume rocker is too flush with the Xoom, and thus it can be incredibly hard to push the buttons sometimes. You'll have your finger on the volume up or down button and swear you're pressing it, but you're not pressing it in the right spot.
7. The speakers are good, not great
8. there's a huge lack of optimized apps for it on the marketplace (like 20 or so). A lot of the un-optimized apps run fine, but some have graphics issues and others crash period. Android 3.0 is brand new and this is the first and only tablet with it, so these issues will likely be addressed with time.

Wow:
1. Flash 10.2 will be available in a few short weeks as will support for microSD cards, so don't let that keep you from purchasing the Xoom.
2. 0 to 100 percent battery life in about 3 hours
3. The Xoom's screen is made from Gorilla Glass which means you won't be neeeding a screen protector anytime soon (unless you don't like a glassy feel)
4. The keyboard is very accurate and the widgets are great. Most android apps work beautifully even if not created for Honeycomb
4. This thing moves fast
5. not noticed one hiccup in speed or performance even when doing the most multitasking on a portable device

Monday, June 07, 2010

Widespread Pollutants with Endocrine-disrupting Effects

Widespread Pollutants
with Endocrine-disrupting Effects

[background information about some common EDCs]

Information is regularly added to this page.
If you have additions--new data on chemicals, references,
corrections or things we missed, etc.--
send information here

Persistent organohalogens

Compound(s)
Hormone system affected

Mechanism if known

References
Benzenehexachloride (BHC)

Thyroid


Akhtar et al. 1996

1,2-dibromoethane

Reproductive

Brittebo et al. 1987

Chloroform

Reproductive

Brittebo et al. 1987

Dioxins and furans

(in order of antiestrogenic potency : 2,3,7,8-tetrachlorodibenzo-p-dioxin > 2,3,7,8-tetrachlorodibenzofuran > 2,3,4,7,8-pentachlorodibenzo-furan > 1,2,3,7,9-pentachlorodibenzofuran > 1,3,6,8-tetrachlo-rodibenzofuran)

Estrogen

work as anti-estrogen through binding with Ah receptor, which then inhibits estrogen receptor binding to estrogen response elements, thereby inhibiting estrogen action

Krishnan and Safe 1993

Klinge et al. 1999

Octachlorostyrene Thyroid Sandan et al. 2000

PBBs

Estrogen/ Thyroid


Bahn et al. 1980

Henderson et al. 1995

PCBs

(in order of antiestrogenic potency: 3,3' -pentachlorobiphenyl > 3,3,4,4,5,5'-hexachlorobiphenyl 3,3',4,4-tetrachlorobiphenyl > 2,3,3',4,4',5'-hexa, 2,3,3',4,4'- and 2,3,4,4',5-pentachlorobiphenyl > Aroclors 1221, 1232. 1248, 1254, and 1260 were inactive as antiestrogens at the highest concentrations used in this study (10-6 Ni)

Estrogen/androgen/Thyroid

Adverse outcomes in reproductive systems.

Inhibits estrogen binding to the receptor; works as anti-estrogen.

anti-androgenic via Ah receptor interaction

Korach et al. 1988

Zoeller et al. 2000

Grey et al. 1999

PCB, hydroxylated

Thyroid

Binds to thyroid hormone binding protein, but not to the thyroid hormone receptor.

Cheek et al. 1999

PBDEs

Thyroid

Interfere with thyroxine (T4) binding with transthryetin

Ilonka et al. 2000

Pentachlorophenol

Thyroid

Reduces thyroid hormone possibly through a direct effect on the thyroid gland.

Bear et al. 1999

Gerhard et al. 1999

Food Antioxidant

Compound
Hormone system affected

Mechanism

References

Butylated hydroxyanisole (BHA)

Estrogen

Inhibits binding to the estrogen receptor.

Jobling et al. 1995

Pesticide (for information organized by pesticide class)

Compound
Hormone system affected

Mechanism

References
Acetochlor

Thyroid (decrease of thyroid hormone levels, increase in TSH)


Hurley et al. 1998

Alachlor

Thyroid (decrease of thyroid hormone levels, increase in TSH)


Wilson et al. 1996

Aldrin

Estrogen

Binds to estrogen receptors; competes with estradiol.

Jorgenson 2001

Allethrin, d-trans

Estrogen


Go et al. 1999

Amitrol

Thyroid

Thyroid peroxidase inhibitors; inhibits thyroid hormone synthesis.

Hurley et al. 1998

Atrazine

Neuroendocrine-pituitary (depression of LH surge), testosterone metabolism.

Inhibits ligand binding to androgen and estrogen receptors.

Danzo 1997

Carbaryl

Estrogen and progesterone


Klotz et al. 1997

Chlofentezine

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Chlordane

Testosterone and progesterone


Willingham et al. 2000

Cypermethrin

Disruption of reproductive function


Moore and Waring 2001

DDT

Estrogen

DDT and related compounds act in a number of ways to disrupt endocrine function by binding with the estrogen receptor, including estrogen mimickry and antagonism, altering the pattern of synthesis or metabolism of hormones, and (4) modifying hormone receptor levels

Soto et al. 1994

Lascombe et al. 2000

Kupfer et al. 1980

Rajapakse et al. 2001

DDT Metabolite, p,p'-DDE

Androgen

Inhibits androgen binding to the androgen receptor, androgen-induced transcriptional activity, and androgen action in developing, pubertal and adult male rats.

Kelce 1995

Dicofol (Kelthane)

Estrogen

Vinggaard et al. 1999

Dieldrin

Estrogen

Binds to estrogen receptor;competes with estradiol.

Soto et al. 1994

Jorgenson 2001

Endosulfan

Estrogen


Soto et al. 1994

Soto et al. 1995

Ethylene thiourea

Thyroid

Thyroid peroxidase inhibitor.

Hurley et al. 1998

Fenarimol

Estrogen

Estrogen receptor agonist.

Vinggaard et al. 1999

Fenbuconazole

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Fenitrothion

Antiandrogen

Competitive androgen receptor antagonist.

Tamura et al. 2001

Fenvalerate

Estrogen


Go et al. 1999

Fipronil

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Heptachlor

Thyroid


Akhtar et al. 1996

Reuber 1987

Heptachlor-epoxide

Thyroid/Reproductive

Metabolite of heptachlor

Reuber 1987

Iprodione

Inhibition of testosterone synthesis


Benhamed 1996

Karate

Thyroid

A decrease of thyroid hormone in serum; direct effect on the thyroid gland?

Akhtar et al. 1996

Kepone (Chlordecone)

Estrogen

Displays androgen and estrogen receptor-binding affinities.

Waller et al. 1996

Soto et al. 1994

McLachlan(ed)

Ketoconazole

Effects on reproductive systems


Marty et al. 1999

Marty et al. 2001

Lindane (Hexachlorocyclohexane)

Estrogen/Androgen

Inhibits ligand binding to androgen and estrogen receptors.

Danzo 1997

Linuron

Androgen

Androgen receptor antagonist.

Waller et al. 1996

Lambright et al. 2000

Grey et al. 1999

Malathion

Thyroid

Significant decrease of thyroid hormone in serum, with perhaps a direct effect on the thyroid gland.

Akhtar et al. 1996

Mancozeb

Thyroid

Thyroid peroxidase inhibitors.

Hurley et al. 1998

Maneb

Thyroid

The metabolite ethylenthiourea inhibits thyroid hormone synthesis.

Toppari et al. 1995

Methomyl

Thyroid


Porter et al. 1993

Klotz et al. 1997

Methoxychlor

Estrogen

Through mechanisms other than receptor antagonism. Precise mechanism still unclear.

Pickford and Morris 1999

Metribuzin

Thyroid


Porter et al. 1993

Mirex

Antiandrogenic activity; inhibits production of LH. Potentially thyroid.


Chen et al. 1986

Chernoff et al. 1976

Nitrofen

Thyroid

Structural similarities to the thyroid hormones; nitrofen or its metabolite may have thyroid hormone activities.

Stevens and Summer 1991

Nonachlor, trans-

Estrogen

Estrogen receptor agonist?

Willingham et al. 2000

Oxychlordane

Reproductive


Guillette et al. 1999

Pendimethalin

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Pentachloronitrobenzene

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Permethrin

Estrogenic


Go et al. 1999

Procymidone

Androgen

Androgen receptor antagonist.

Ostby et al. 1999

Grey et al. 1999

Prodiamine

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Pyrimethanil

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Sumithrin

Androgen


Go et al. 1999

Tarstar

Thyroid

A decrease of thyroid hormone in serum; direct effect on the thyroid gland?

Akhtar et al. 1996

Thiazopyr

Thyroid

Enhances secretion of thyroid hormone.

Hurley et al. 1998

Thiram

Neuroendocrine-pituitary (depression of LH surge), thyroid (decrease of T4, increase of TSH)


Stoker et al. 1993

Toxaphene

Estrogen/ Thyroid


Soto et al. 1994

Triadimefon

Estrogen

Estrogen receptor agonist.

Vinggaard et al. 1999

Triadimenol

Estrogen

Estrogen receptor agonist

Vinggaard et al. 1999

Tributyltin

Reproductive


Horiguchi et al. 2000

Trifluralin

Reproductive/ Metabolic


Rawlings et al. 1998

Vinclozolin

Androgen

Anti-androgenic. (Competes with androgens for the androgen receptor (AR), inhibits AR-DNA binding, and alters androgen-dependent gene expression.)

Soto et al. 1994

Soto et al. 1995

Kelce et al. 1994

Grey et al. 1999

Zineb

Thyroid

The metabolite ethylenthiourea inhibits thyroid hormone synthesis.

Toppari et al. 1995

Ziram

Thyroid

Inhibits the iodide peroxidase. Structural similarities between ziram and thiram; ziram can be metabolized to thiram in the environment.

Marinovich et al. 1997

Phthalate

Compound
Hormones affected

Mechanism

References
Butyl benzyl phthalate (BBP)

Estrogen

Inhibits binding to the estrogen receptor

Jobling et al. 1995

Di-n-butyl phthalate (DBP)

Estrogen

Androgen

Inhibits binding to the estrogen receptor.

anti-androgenic

Jobling et al. 1995

Harris et al. 1997

Grey et al. 1999

Di-ethylhexyl phthalate (DEHP)

Estrogen

Androgen

Inhibits binding to the estrogen receptor.

anti-androgenic

Jobling et al. 1995

Harris et al. 1997

Moore et al. 2001

Grey et al. 1999

Diethyl Phthalate (DEP)

Estrogen


Harris et al. 1997

Other Compounds

Compound
Hormones affected

Mechanism

References

Benzophenone

Estrogen

Binds weakly to estrogen receptors, roles of its metabolite remain to be clarified.

Schlumpf et al. 2001

Bisphenol A

Estrogen

Estrogenic; binds to estrogen receptor

Fisher et al. 1999

Anderson et al. 1999

Rajapakse et al. 2001

Bisphenol F

Estrogen

Estrogenic; b inds to estrogen receptor

Perez et al. 1998

Benzo(a)pyrene

Androgen

anti-androgenic

Thomas 1990

Carbendazim

Reproductive


Gray et al. 1990

Ethane Dimethane Sulphonate

Reproductive


Gray et al. 1999

Perfluorooctane sulfonate
(PFOS)

Thyroid, reproductive

suppression of T3,T4; mechanism unknown

3M data

Nonylphenol, octylphenol

Estrogen

Estrogen receptor agonists; reduces estradiol binding to the estrogen receptor.

Soto et al. 1991

Soto et al. 1995

Danzo 1997

Lascombe et al. 2000

Rajapakse et al. 2001

Resorcinol

Thyroid

Lindsay et al. 1989

Styrene dimers and trimers

Estrogen

Estrogen receptor agonists

Ohyama et al. 2001

Metals

Compound
Hormones affected

Mechanism

References
Arsenic

Glucocorticoid

Selective inhibition of DNA transcription normally stimulated by the glucocorticoid-GR complex.

Kaltreider et al. 2001

Cadmium

Estrogenic

Activates estrogen receptor through an interaction with the hormone-binding domain of the receptor.

Stoica et al. 2000

Johnson et al. 2003

Lead

Reproductive


Telisman et al. 2000

Hanas et al. 1999

Mercury

Reproductive/ Thyroid


Facemire et al. 1995